Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Polymorphism rs2274911 of GPRC6A as a Novel Risk Factor for Testis Failure.

The Journal of clinical endocrinology and metabolism - 1 Mar 2016

De Toni Luca, Di Nisio Andrea, Speltra Elena, Rocca Maria Santa, Ghezzi Marco, Zuccarello Daniela, Turiaco Nunzio, Ferlin Alberto, Foresta Carlo

Abstract excerpt

CONTEXT: The G protein-coupled receptor GPRC6A is an emerging effector with multiple endocrine roles, including stimulation of T production from the testis. Recently, two men with an inactivating mutation (F464Y) of GPRC6A have been identified, and they showed primary testicular failure and deranged spermatogenesis. Furthermore, one of them also reported cryptorchidism at birth. In addition, a polymorphism...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cryptorchidism
Share to Follicle Stimulating Hormone

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Homozygote

Share to Infant, Newborn

Share to Infertility, Male

Share to Luteinizing Hormone

Share to Receptors, G-Protein-Coupled

Share to Testosterone

Source

Identifiers

PMID: 26735260
DOI: 10.1210/jc.2015-3967

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Polymorphism rs2274911 of GPRC6A as a Novel Risk Factor for Testis Failure.PMID 26735260Read ↗

rs2274911 polymorphism in GPRC6A associated with serum E2 and PSA in a Southern Chinese male population.Semantic proximity Read ↗

Biallelic RXFP2 variants lead to congenital bilateral cryptorchidism and male infertility, supporting a role of RXFP2 in spermatogenesis.Semantic proximity Read ↗

gr/gr deletion predisposes to testicular germ cell tumour independently from altered spermatogenesis: results from the largest European studySemantic proximity Read ↗

Follicle stimulating hormone receptor G-29A, 919A>G, 2039A>G polymorphism and the risk of male infertility: a meta-analysis.Semantic proximity Read ↗

Mutational screening of NR5A1 gene encoding steroidogenic factor 1 in cryptorchidism and male factor infertility and functional analysis of seven undescribed mutations.Semantic proximity Read ↗

Polymorphisms of the luteinizing hormone/chorionic gonadotropin receptor gene: association with maldescended testes and male infertility.Semantic proximity Read ↗

PDE11A gene polymorphism in testicular cancer: sperm parameters and hormonal profile.Semantic proximity Read ↗

Subfertility and Risk of Testicular Cancer in the EPSAM Case-Control Study.Semantic proximity Read ↗

The Y deletion gr/gr and susceptibility to testicular germ cell tumor.Semantic proximity Read ↗

Is the FSHR 2039A>G variant associated with susceptibility to testicular germ cell cancer?Semantic proximity Read ↗

GPER and Testicular Germ Cell CancerSemantic proximity Read ↗

Mutation screening of the FKBP6 gene and its association study with spermatogenic impairment in idiopathic infertile men.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.