Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Association study of the BIN1 and IL-6 genes on Alzheimer's disease.

Neuroscience letters - 12 Feb 2016

Ramos Dos Santos Lígia, Belcavello Luciano, Camporez Daniela, Iamonde Maciel de Magalhães Caerê, Zandonade Eliana, Lírio Morelato Renato, Imbroisi Valle Errera Flavia, Drumond Louro Iuri, Do Carmo Pimentel Batitucci Marial, de Paula Flavia

Abstract excerpt

Genome-wide association study (GWAS) has identified several novel genes associated with the risk of Alzheimer's disease (AD), which is a progressive neurodegenerative disease in elders. However, most of the novel genes have not been validated through replication in separated populations. Among them, the BIN1 gene is involved in endocytosis and intracellular trafficking as well as in the formation of β amyloid...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adaptor Proteins, Signal Transducing
Share to Aged, 80 and over

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Alzheimer Disease

Share to Case-Control Studies

Share to Genetic Association Studies

Share to Interleukin-6

Share to Nuclear Proteins

Share to Tumor Suppressor Proteins

Source

Identifiers

PMID: 26733302
DOI: 10.1016/j.neulet.2015.12.046

Genes

BIN1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Association study of the BIN1 and IL-6 genes on Alzheimer's disease.PMID 26733302Read ↗

Sequence variants of interleukin 6 (IL-6) are significantly associated with a decreased risk of late-onset Alzheimer's disease.Semantic proximity Read ↗

IL-6-174 G/C and -572 C/G polymorphisms and risk of Alzheimer's disease.Semantic proximity Read ↗

Interleukin-6 gene (-174 C/G ) and apolipoprotein E gene polymorphisms and the risk of Alzheimer disease in a Polish population.Semantic proximity Read ↗

Convergent lines of evidence support BIN1 as a risk gene of Alzheimer's disease.Semantic proximity Read ↗

Inflammation in Alzheimer’s Disease and Molecular Genetics: Recent UpdateSemantic proximity Read ↗

Association Between Interleukin-1A, Interleukin-1B, and Bridging integrator 1 Polymorphisms and Alzheimer's Disease: a standard and Cumulative Meta-analysis.Semantic proximity Read ↗

Updated Meta-Analysis of BIN1, CR1, MS4A6A, CLU, and ABCA7 Variants in Alzheimer's Disease.Semantic proximity Read ↗

Genetic evidence for the involvement of variants at APOE, BIN1, CR1, and PICALM loci in risk of late-onset Alzheimer's disease and evaluation for interactions with APOE genotypes.Semantic proximity Read ↗

Plasma IL-6 levels and their association with brain health and dementia risk: A population-based cohort study.Semantic proximity Read ↗

Interleukin-6 -174G/C polymorphism and the risk of Alzheimer's disease in Caucasians: a meta-analysis.Semantic proximity Read ↗

Association between interleukin 6 gene haplotype and Alzheimer's disease: a Brazilian case-control study.Semantic proximity Read ↗

Blood Interleukin-6 (IL-6) mRNA Expression in Alzheimer’s Disease: A Preliminary AnalysisSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.