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Article

Overexpression of Swedish mutant APP in aged astrocytes attenuates excitatory synaptic transmission.

Physiological reports - 1 Jan 2016

Katsurabayashi Shutaro, Kawano Hiroyuki, Ii Miyuki, Nakano Sachiko, Tatsumi Chihiro, Kubota Kaori, Takasaki Kotaro, Mishima Kenichi, Fujiwara Michihiro, Iwasaki Katsunori

Abstract excerpt

Amyloid precursor protein (APP), a type I transmembrane protein, has different aspects, namely, performs essential physiological functions and produces β-amyloid peptide (Aβ). Overexpression of neuronal APP is responsible for synaptic dysfunction. In the central nervous system, astrocytes - a major glial cell type - have an important role in the regulation of synaptic transmission. Although APP is expressed in...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 26733247
DOI: 10.14814/phy2.12665
PMCID: PMC4760399

Genes

APP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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