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Article

Comparison of normalization and differential expression analyses using RNA-Seq data from 726 individual Drosophila melanogaster.

BMC genomics - 5 Jan 2016

Lin Yanzhu, Golovnina Kseniya, Chen Zhen-Xia, Lee Hang Noh, Negron Yazmin L Serrano, Sultana Hina, Oliver Brian, Harbison Susan T

Abstract excerpt

BACKGROUND: A generally accepted approach to the analysis of RNA-Seq read count data does not yet exist. We sequenced the mRNA of 726 individuals from the Drosophila Genetic Reference Panel in order to quantify differences in gene expression among single flies. One of our experimental goals was to identify the optimal analysis approach for the detection of differential gene expression among the factors we varied...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 26732976
DOI: 10.1186/s12864-015-2353-z
PMCID: PMC4702322

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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