Article
Genome-Wide Association Analysis of Young-Onset Stroke Identifies a Locus on Chromosome 10q25 Near HABP2.
Stroke - 1 Feb 2016
Cheng Yu-Ching, Stanne Tara M, Giese Anne-Katrin, Ho Weang Kee, Traylor Matthew, Amouyel Philippe, Holliday Elizabeth G, Malik Rainer, Xu Huichun, Kittner Steven J, Cole John W, O'Connell Jeffrey R, Danesh John, Rasheed Asif, Zhao Wei, Engelter Stefan, Grond-Ginsbach Caspar, Kamatani Yoichiro, Lathrop Mark, Leys Didier, Thijs Vincent, Metso Tiina M, Tatlisumak Turgut, Pezzini Alessandro, Parati Eugenio A, Norrving Bo, Bevan Steve, Rothwell Peter M, Sudlow Cathie, Slowik Agnieszka, Lindgren Arne, Walters Matthew R, Jannes Jim, Shen Jess, Crosslin David, Doheny Kimberly, Laurie Cathy C, Kanse Sandip M, Bis Joshua C, Fornage Myriam, Mosley Thomas H, Hopewell Jemma C, Strauch Konstantin, Müller-Nurasyid Martina, Gieger Christian, Waldenberger Melanie, Peters Annette, Meisinger Christine, Ikram M Arfan, Longstreth W T, Meschia James F, Seshadri Sudha, Sharma Pankaj, Worrall Bradford, Jern Christina, Levi Christopher, Dichgans Martin, Boncoraglio Giorgio B, Markus Hugh S, Debette Stephanie, Rolfs Arndt, Saleheen Danish, Mitchell Braxton D
Abstract excerpt
BACKGROUND AND PURPOSE: Although a genetic contribution to ischemic stroke is well recognized, only a handful of stroke loci have been identified by large-scale genetic association studies to date. Hypothesizing that genetic effects might be stronger for early- versus late-onset stroke, we conducted a 2-stage meta-analysis of genome-wide association studies, focusing on stroke cases with an age of onset <60...
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