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Early events in the generation of autophagosomes are required for the formation of membrane structures involved in hepatitis C virus genome replication

4 Jan 2016

Abstract excerpt

Hepatitis C virus (HCV) infection has been shown to induce autophagy but the mechanisms underpinning this process remain to be elucidated. Induction of autophagy requires the class III phosphatidylinositol 3-kinase, Vps34, which produces phosphatidylinositol 3-phosphate (PI3P) within the endoplasmic reticulum (ER) membrane. This recruits proteins with PI3P binding domains such as the double-FYVE-containing...

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PMID: 26727924
DOI: 10.1099/jgv.0.000387

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