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Article

Replication of Hepatitis C Virus RNA on Autophagosomal Membranes

11 Apr 2012

Abstract excerpt

Previous studies indicated that hepatitis C virus (HCV) perturbs the autophagic pathway to induce the accumulation of autophagosomes in cells. To understand the role of autophagosomes in the HCV life cycle, we established a stable Huh7 hepatoma cell line that contained an HCV subgenomic RNA replicon and also expressed a GFP-LC3 fusion protein. The GFP-LC3 protein is localized to autophagosomes during autophagy...

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PMID: 22496373
DOI: 10.1074/jbc.m111.320085

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