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Article

Oxysterol-binding protein is a phosphatidylinositol 4-kinase effector required for HCV replication membrane integrity and cholesterol trafficking.

Gastroenterology - 1 May 2014

Wang Hongliang, Perry Jeffrey W, Lauring Adam S, Neddermann Petra, De Francesco Raffaele, Tai Andrew W

Abstract excerpt

BACKGROUND & AIMS: Positive-sense RNA viruses remodel intracellular membranes to generate specialized membrane compartments for viral replication. Several RNA viruses, including poliovirus and hepatitis C virus (HCV), require phosphatidylinositol (PI) 4-kinases for their replication. However, it is not known how PI 4-kinases and their product, PI(4)P, facilitate host membrane reorganization and viral replication....

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Identifiers

PMID: 24512803
DOI: 10.1053/j.gastro.2014.02.002
PMCID: PMC3992183

Genes

OSBP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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