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Article

Contribution of autophagy machinery factors to HCV and SARS-CoV-2 replication organelle formation

1 Nov 2021

Abstract excerpt

Positive-strand RNA viruses replicate in close association with rearranged intracellular membranes. For hepatitis C virus (HCV) and severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), these rearrangements comprise endoplasmic reticulum (ER)-derived double membrane vesicles (DMVs) serving as RNA replication sites. Cellular factors involved in DMV biogenesis are poorly defined. Here, we show that despite...

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PMID: 34788596
DOI: 10.1016/j.celrep.2021.110049

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