Article
Crystal structure of human PACRG in complex with MEIG1 reveals roles in axoneme formation and tubulin binding.
Structure (London, England : 1993) - 3 Jun 2021
Khan Nimra, Pelletier Dylan, McAlear Thomas S, Croteau Nathalie, Veyron Simon, Bayne Andrew N, Black Corbin, Ichikawa Muneyoshi, Khalifa Ahmad Abdelzaher Zaki, Chaaban Sami, Kurinov Igor, Brouhard Gary, Bechstedt Susanne, Bui Khanh Huy, Trempe Jean-François
Abstract excerpt
The Parkin co-regulated gene protein (PACRG) binds at the inner junction between doublet microtubules of the axoneme, a structure found in flagella and cilia. PACRG binds to the adaptor protein meiosis expressed gene 1 (MEIG1), but how they bind to microtubules is unknown. Here, we report the crystal structure of human PACRG in complex with MEIG1. PACRG adopts a helical repeat fold with a loop that interacts with...
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