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Article

Adjuvanted influenza-H1N1 vaccination reveals lymphoid signatures of age-dependent early responses and of clinical adverse events.

Nature immunology - 1 Feb 2016

Sobolev Olga, Binda Elisa, O'Farrell Sean, Lorenc Anna, Pradines Joel, Huang Yongqing, Duffner Jay, Schulz Reiner, Cason John, Zambon Maria, Malim Michael H, Peakman Mark, Cope Andrew, Capila Ishan, Kaundinya Ganesh V, Hayday Adrian C

Abstract excerpt

Adjuvanted vaccines afford invaluable protection against disease, and the molecular and cellular changes they induce offer direct insight into human immunobiology. Here we show that within 24 h of receiving adjuvanted swine flu vaccine, healthy individuals made expansive, complex molecular and cellular responses that included overt lymphoid as well as myeloid contributions. Unexpectedly, this early response was...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 26726811
DOI: 10.1038/ni.3328
PMCID: PMC6485475

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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