Article

LiteVax-adjuvanted influenza vaccine induces transient interferon-driven innate activation and accelerates early IgG3 responses in older adults

2026-07-31

Abstract excerpt

Vaccine immunogenicity declines with age due to immunosenescence, underscoring the need for improved adjuvants. LiteVax Adjuvant (LVA), a squalane-in-water emulsion containing carbohydrate fatty-acid monosulphate esters, has shown potential to enhance influenza vaccine responses, but its mechanisms in humans remain unclear. We performed a longitudinal systems vaccinology study in 56 younger (18-45 years) and older...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: a5359dfc-1149-52ba-9da8-64a393a94326
DOI: 10.64898/2026.07.28.741158

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

LiteVax-adjuvanted influenza vaccine induces transient interferon-driven innate activation and accelerates early IgG3 responses in older adultsDOI 10.64898/2026.07.28.741158Read

LiteVax-adjuvanted influenza vaccine induces transient interferon-driven innate activation and accelerates early IgG3 responses in older adultsSemantic proximity Read

Antiviral CD4 <sup>+</sup> T and myeloid cell responses to influenza vaccines are attenuated in older adultsSemantic proximity Read

Longitudinal Multi-omic Immune Profiling Reveals Age-Related Immune Cell Dynamics in Healthy AdultsSemantic proximity Read

Harnessing Human Immune Organoid model for Systemic and Comparative Analysis of Clinically Vaccine AdjuvantsSemantic proximity Read

Systems vaccinology: probing humanity's diverse immune systems with vaccines.Semantic proximity Read

Systems Vaccinology Reveals Distinct Immune Signatures of Inhaled and Intramuscular SARS-CoV-2 Vaccination in HumansSemantic proximity Read

Adjuvanted influenza-H1N1 vaccination reveals lymphoid signatures of age-dependent early responses and of clinical adverse events.Semantic proximity Read

Adjuvantation of a SARS-CoV-2 mRNA vaccine with controlled tissue-specific expression of an mRNA encoding IL-12p70Semantic proximity Read

Multiscale dynamic immunomodulation by a nanoemulsified Trojan-TLR7/8 adjuvant for robust protection against heterologous pandemic and endemic virusesSemantic proximity Read

Impact of Vaccines Across the Lifespan: A New Perspective in Public Health – Conclusions of an Expert Panel – Part 2Semantic proximity Read

Poly-γ-Glutamic Acid/Alum Adjuvanted pH1N1 Vaccine-Immunized Aged Mice Exhibit a Significant Increase In Vaccine Efficacy With a Decrease in Age-Associated CD8+ T Cell Proportion in SplenocytesSemantic proximity Read

Influenza vaccination features revealed by a single‐cell transcriptome atlasSemantic proximity Read