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Article

Genetics and Epigenetics of Bone Remodeling and Metabolic Bone Diseases.

International journal of molecular sciences - 28 Jan 2022

Oton-Gonzalez Lucia, Mazziotta Chiara, Iaquinta Maria Rosa, Mazzoni Elisa, Nocini Riccardo, Trevisiol Lorenzo, D'Agostino Antonio, Tognon Mauro, Rotondo John Charles, Martini Fernanda

Abstract excerpt

Bone metabolism consists of a balance between bone formation and bone resorption, which is mediated by osteoblast and osteoclast activity, respectively. In order to ensure bone plasticity, the bone remodeling process needs to function properly. Mesenchymal stem cells differentiate into the osteoblast lineage by activating different signaling pathways, including transforming growth factor β (TGF-β)/bone...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 35163424
DOI: 10.3390/ijms23031500
PMCID: PMC8836080

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