SNPs in bone-related miRNAs are associated with the osteoporotic phenotype.

doi:10.1038/s41598-017-00641-7

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Article

SNPs in bone-related miRNAs are associated with the osteoporotic phenotype.

Scientific reports - 31 Mar 2017

De-Ugarte Laura, Caro-Molina Enrique, Rodríguez-Sanz Maria, García-Pérez Miguel Angel, Olmos José M, Sosa-Henríquez Manuel, Pérez-Cano Ramón, Gómez-Alonso Carlos, Del Rio Luis, Mateo-Agudo Jesús, Blázquez-Cabrera José Antonio, González-Macías Jesús, Pino-Montes Javier Del, Muñoz-Torres Manuel, Diaz-Curiel Manuel, Malouf Jorge, Cano Antonio, Pérez-Castrillon José Luis, Nogues Xavier, Garcia-Giralt Natalia, Diez-Perez Adolfo

Abstract excerpt

Biogenesis and function of microRNAs can be influenced by genetic variants in the pri-miRNA sequences leading to phenotypic variability. This study aims to identify single nucleotide polymorphisms (SNPs) affecting the expression levels of bone-related mature microRNAs and thus, triggering an osteoporotic phenotype. An association analysis of SNPs located in pri-miRNA sequences with bone mineral density (BMD) was...

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Identifiers

PMID: 28364128
DOI: 10.1038/s41598-017-00641-7
PMCID: PMC5428869

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