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Article

Dual role of tumour-infiltrating T helper 17 cells in human colorectal cancer.

Gut - 1 Apr 2017

Amicarella F, Muraro M G, Hirt C, Cremonesi E, Padovan E, Mele V, Governa V, Han J, Huber X, Droeser R A, Zuber M, Adamina M, Bolli M, Rosso R, Lugli A, Zlobec I, Terracciano L, Tornillo L, Zajac P, Eppenberger-Castori S, Trapani F, Oertli D, Iezzi G

Abstract excerpt

BACKGROUND: The immune contexture predicts prognosis in human colorectal cancer (CRC). Whereas tumour-infiltrating CD8+ T cells and myeloid CD16+ myeloperoxidase (MPO)+ cells are associated with favourable clinical outcome, interleukin (IL)-17-producing cells have been reported to correlate with severe prognosis. However, their phenotypes and functions continue to be debated. OBJECTIVE: To investigate clinical...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 26719303
DOI: 10.1136/gutjnl-2015-310016
PMCID: PMC5529969

Genes

MPO
CCL20
CCL5
CCR5
CCR6

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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