Article
CD8(+) T cells that produce interleukin-17 regulate myeloid-derived suppressor cells and are associated with survival time of patients with gastric cancer.
Gastroenterology - 1 Oct 2012
Zhuang Yuan, Peng Liu-Sheng, Zhao Yong-Liang, Shi Yun, Mao Xu-Hu, Chen Weisan, Pang Ken C, Liu Xiao-Fei, Liu Tao, Zhang Jin-Yu, Zeng Hao, Liu Kai-Yun, Guo Gang, Tong Wen-De, Shi Yan, Tang Bin, Li Na, Yu Shu, Luo Ping, Zhang Wei-Jun, Lu Dong-Shui, Yu Pei-Wu, Zou Quan-Ming
Abstract excerpt
BACKGROUND & AIMS: CD8(+) T cells that produce interleukin (IL)-17 (Tc17 cells) promote inflammation and have been identified in tumors. We investigated their role in the pathogenesis of gastric cancer. METHODS: We used flow cytometry analyses to determine levels and phenotype of Tc17 cells in blood and tumor samples from 103 patients with gastric cancer. We performed multivariate analysis to identify factors...
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