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Article

Natural selection against a circadian clock gene mutation in mice.

Proceedings of the National Academy of Sciences of the United States of America - 19 Jan 2016

Spoelstra Kamiel, Wikelski Martin, Daan Serge, Loudon Andrew S I, Hau Michaela

Abstract excerpt

Circadian rhythms with an endogenous period close to or equal to the natural light-dark cycle are considered evolutionarily adaptive ("circadian resonance hypothesis"). Despite remarkable insight into the molecular mechanisms driving circadian cycles, this hypothesis has not been tested under natural conditions for any eukaryotic organism. We tested this hypothesis in mice bearing a short-period mutation in the...

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Identifiers

PMID: 26715747
DOI: 10.1073/pnas.1516442113
PMCID: PMC4725470

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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