Article
Natural selection against a circadian clock gene mutation in mice.
Proceedings of the National Academy of Sciences of the United States of America - 19 Jan 2016
Spoelstra Kamiel, Wikelski Martin, Daan Serge, Loudon Andrew S I, Hau Michaela
Abstract excerpt
Circadian rhythms with an endogenous period close to or equal to the natural light-dark cycle are considered evolutionarily adaptive ("circadian resonance hypothesis"). Despite remarkable insight into the molecular mechanisms driving circadian cycles, this hypothesis has not been tested under nat...
Topics
- Aging
- Alleles
- Animals
- Casein Kinase I
- Circadian Clocks
- Circadian Rhythm
- Feeding Behavior
- Female
- Gene Frequency
- Genotype
- Male
- Mice, Inbred C57BL
- Mutation
- Selection, Genetic
- Survival Analysis