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Live births after simultaneous avoidance of monogenic diseases and chromosome abnormality by next-generation sequencing with linkage analyses.

Proceedings of the National Academy of Sciences of the United States of America - 29 Dec 2015

Yan Liying, Huang Lei, Xu Liya, Huang Jin, Ma Fei, Zhu Xiaohui, Tang Yaqiong, Liu Mingshan, Lian Ying, Liu Ping, Li Rong, Lu Sijia, Tang Fuchou, Qiao Jie, Xie X Sunney

Abstract excerpt

In vitro fertilization (IVF), preimplantation genetic diagnosis (PGD), and preimplantation genetic screening (PGS) help patients to select embryos free of monogenic diseases and aneuploidy (chromosome abnormality). Next-generation sequencing (NGS) methods, while experiencing a rapid cost reduction, have improved the precision of PGD/PGS. However, the precision of PGD has been limited by the false-positive and...

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Identifiers

PMID: 26712022
DOI: 10.1073/pnas.1523297113
PMCID: PMC4702982

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PGD

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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