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Article

Novel PGD strategy based on single sperm linkage analysis for carriers of single gene pathogenic variant and chromosome reciprocal translocation.

Journal of assisted reproduction and genetics - 1 May 2020

Wang Yuqian, Zhu Xiaohui, Yan Zhiqiang, Zhi Xu, Guan Shuo, Kuo Ying, Nie Yanli, Lian Ying, Huang Jin, Wei Yuan, Liu Ping, Li Rong, Qiao Jie, Yan Liying

Abstract excerpt

PURPOSE: Preimplantation genetic diagnosis (PGD) analysis can be challenging for couples who carry more than one genetic condition. In this study, we describe a new PGD strategy to select which embryo(s) to transfer for two clinically challenging cases. Both cases lack essential family members for linkage analysis including de novo mutation combined with reciprocal translocation. METHODS: Diverging from...

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Identifiers

PMID: 32350783
DOI: 10.1007/s10815-020-01753-2
PMCID: PMC7244654

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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