Genotyping single-sperm cells by universal MARSALA enables the acquisition of linkage information for combined pre-implantation genetic diagnosis and genome screening.

doi:10.1007/s10815-018-1158-9

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Article

Genotyping single-sperm cells by universal MARSALA enables the acquisition of linkage information for combined pre-implantation genetic diagnosis and genome screening.

Journal of assisted reproduction and genetics - 1 Jun 2018

Wu Haitao, Shen Xiaoting, Huang Lei, Zeng Yanhong, Gao Yumei, Shao Lin, Lu Baomin, Zhong Yiping, Miao Benyu, Xu Yanwen, Wang Yali, Li Yubin, Xiong Luoxing, Lu Sijia, Xie X Sunney, Zhou Canquan

Abstract excerpt

PURPOSE: This paper aims to investigate the feasibility of performing pre-implantation genetic diagnosis (PGD) and pre-implantation genetic screening (PGS) simultaneously by a universal strategy without the requirement of genotyping relevant affected family members or lengthy preliminary work on linkage analysis. METHODS: By utilizing a universal Mutated Allele Revealed by Sequencing with Aneuploidy and Linkage...

Topics

Adult
Aneuploidy
Chromosome Disorders
Embryo Transfer
Female
Fertilization in Vitro
Genetic Linkage
Genetic Testing
Genome, Human
Genotype

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

High-Throughput Nucleotide Sequencing

Humans

Male

Mutation

Polymorphism, Single Nucleotide

Pregnancy

Preimplantation Diagnosis

Spermatozoa

Source

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Identifiers

PMID: 29790070
DOI: 10.1007/s10815-018-1158-9
PMCID: PMC6030017

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