Article
Human Gut-Commensalic Lactobacillus ruminis ATCC 25644 Displays Sortase-Assembled Surface Piliation: Phenotypic Characterization of Its Fimbrial Operon through In Silico Predictive Analysis and Recombinant Expression in Lactococcus lactis.
PloS one - 1 Jan 2015
Yu Xia, Jaatinen Annukka, Rintahaka Johanna, Hynönen Ulla, Lyytinen Outi, Kant Ravi, Åvall-Jääskeläinen Silja, von Ossowski Ingemar, Palva Airi
Abstract excerpt
Sortase-dependent surface pili (or fimbriae) in Gram-positive bacteria are well documented as a key virulence factor for certain harmful opportunistic pathogens. However, it is only recently known that these multi-subunit protein appendages are also belonging to the "friendly" commensals and now, with this new perspective, they have come to be categorized as a niche-adaptation factor as well. In this regard, it...
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