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Article

H274Y's Effect on Oseltamivir Resistance: What Happens Before the Drug Enters the Binding Site.

Journal of chemical information and modeling - 25 Jan 2016

Yusuf Muhammad, Mohamed Nornisah, Mohamad Suriyati, Janezic Dusanka, Damodaran K V, Wahab Habibah A

Abstract excerpt

Increased reports of oseltamivir (OTV)-resistant strains of the influenza virus, such as the H274Y mutation on its neuraminidase (NA), have created some cause for concern. Many studies have been conducted in the attempt to uncover the mechanism of OTV resistance in H274Y NA. However, most of the reported studies on H274Y focused only on the drug-bound system, so the direct effects of the mutation on NA itself...

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Source

Identifiers

PMID: 26703840
DOI: 10.1021/acs.jcim.5b00331

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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