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Article

Permissive secondary mutations enable the evolution of influenza oseltamivir resistance.

Science (New York, N.Y.) - 4 Jun 2010

Bloom Jesse D, Gong Lizhi Ian, Baltimore David

Abstract excerpt

The His274-->Tyr274 (H274Y) mutation confers oseltamivir resistance on N1 influenza neuraminidase but had long been thought to compromise viral fitness. However, beginning in 2007-2008, viruses containing H274Y rapidly became predominant among human seasonal H1N1 isolates. We show that H274Y decr...

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Share to Antiviral Agents
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Influenza A Virus, H1N1 Subtype

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Source

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Identifiers

PMID: 20522774
DOI: 10.1126/science.1187816
PMCID: PMC2913718

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-20522774-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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