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Article

Outside-binding site mutations modify the active site's shapes in neuraminidase from influenza A H1N1.

Biopolymers - 1 Jan 2013

Tolentino-Lopez Luis, Segura-Cabrera Aldo, Reyes-Loyola Paola, Zimic Mirko, Quiliano Miguel, Briz Veronica, Muñoz-Fernández Angeles, Rodríguez-Pérez Mario, Ilizaliturri-Flores Ian, Correa-Basurto Jose

Abstract excerpt

The recent occurrence of 2009 influenza A (H1N1) pandemic as well as others has raised concern of a far more dangerous outcome should this virus becomes resistant to current drug therapies. The number of clinical cases that are resistant to oseltamivir (Tamiflu®) is larger than the limited number of neuraminidase (NA) mutations (H275Y, N295S, and I223R) that have been identified at the active site and that are...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 23097226
DOI: 10.1002/bip.22130

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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