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Source of oseltamivir resistance in avian influenza H5N1 virus with the H274Y mutation.

Amino acids - 1 Oct 2009

Malaisree Maturos, Rungrotmongkol Thanyada, Nunthaboot Nadtanet, Aruksakunwong Ornjira, Intharathep Pathumwadee, Decha Panita, Sompornpisut Pornthep, Hannongbua Supot

Abstract excerpt

Molecular dynamics simulations were carried out for the mutant oseltamivir-NA complex, to provide detailed information on the oseltamivir-resistance resulting from the H274Y mutation in neuraminidase (NA) of avian influenza H5N1 viruses. In contrast with a previous proposal, the H274Y mutation does not prevent E276 and R224 from forming the hydrophobic pocket for the oseltamivir bulky group. Instead, reduction of...

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PMID: 19002747
DOI: 10.1007/s00726-008-0201-z

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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