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Hepatitis C virus utilizes VLDLR as a novel entry pathway

23 Dec 2015

Abstract excerpt

Various host factors are involved in the cellular entry of hepatitis C virus (HCV). In addition to the factors previously reported, we discovered that the very-low-density lipoprotein receptor (VLDLR) mediates HCV entry independent of CD81. Culturing Huh7.5 cells under hypoxic conditions significantly increased HCV entry as a result of the expression of VLDLR, which was not expressed under normoxic conditions in...

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PMID: 26699506
DOI: 10.1073/pnas.1506524113

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