Article
Obesity-related known and candidate SNP markers can significantly change affinity of TATA-binding protein for human gene promoters.
BMC genomics - 1 Jan 2015
Arkova Olga V, Ponomarenko Mikhail P, Rasskazov Dmitry A, Drachkova Irina A, Arshinova Tatjana V, Ponomarenko Petr M, Savinkova Ludmila K, Kolchanov Nikolay A
Abstract excerpt
BACKGROUND: Obesity affects quality of life and life expectancy and is associated with cardiovascular disorders, cancer, diabetes, reproductive disorders in women, prostate diseases in men, and congenital anomalies in children. The use of single nucleotide polymorphism (SNP) markers of diseases and drug responses (i.e., significant differences of personal genomes of patients from the reference human genome) can...
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