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Article

COMT Val158Met polymorphism and executive functions in obsessive-compulsive disorder.

The Journal of neuropsychiatry and clinical neurosciences - 1 Jan 2013

Tükel Raşit, Gürvit Hakan, Öztürk Nalan, Özata Berna, Ertekin Banu Aslantaş, Ertekin Erhan, Baran Bengi, Kalem Şiükriye Akça, Büyükgök Deniz, Direskeneli Güher Saruhan

Abstract excerpt

This study investigated the association between the catechol-O-methyl transferase (COMT) Val158Met polymorphism and executive functions in 101 patients with obsessive-compulsive disorder (OCD) and 100 healthy-control subjects (HS). Results showed that there was no significant difference for the genotype distributions between the OCD and HS groups. OCD-Met carrier subgroup's TMT B-A difference and lexical fluency...

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Source

Identifiers

PMID: 23774999
DOI: 10.1176/appi.neuropsych.12040103

Genes

COMT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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COMT Val158Met polymorphism and executive functions in obsessive-compulsive disorder.PMID 23774999Read ↗

Catechol-O-methyltransferase gene Val158Met polymorphism and obsessive compulsive disorder susceptibility: a meta-analysis.Semantic proximity Read ↗

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Catechol-O-Methyltransferase Gene Polymorphisms in Specific Obsessive-Compulsive Disorder Patients' Subgroups.Semantic proximity Read ↗

No association between the COMT Val158Met polymorphism and the long-term clinical response in obsessive-compulsive disorder in the Japanese population.Semantic proximity Read ↗

Relation between executive functions and polymorphisms in COMT, MAO-A, HTTLPR, SLC1A1 and HT2A in a sample of children with Obsessive Compulsive DisorderSemantic proximity Read ↗

Reduced 3-O-methyl-dopa levels in OCD patients and their unaffected parents is associated with the low activity M158 COMT allele.Semantic proximity Read ↗

A case-control association study of COMT rs4680 Polymorphism with Obsessive-Compulsive Disorder and Cognitive Functions: The role of sexSemantic proximity Read ↗

Association between the Catechol O-methyltransferase (COMT) Val158met polymorphism and different dimensions of impulsivity.Semantic proximity Read ↗

The role of the COMT Val(158)Met polymorphism in the phenotypic expression of obsessive-compulsive disorder.Semantic proximity Read ↗

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