Vitamin D receptor polymorphisms and expression profile in rheumatoid arthritis Brazilian patients.

doi:10.1007/s11033-015-3937-z

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Vitamin D receptor polymorphisms and expression profile in rheumatoid arthritis Brazilian patients.

Molecular biology reports - 1 Jan 2016

Cavalcanti Catarina Addobbati Jordão, Silva Jaqueline de Azevêdo, Pita Will de Barros, Veit Tiago Degani, Monticielo Odirlei Andre, Xavier Ricardo Machado, Brenol João Carlos Tavares, Brenol Cleiton Viegas, Fragoso Thiago Sotero, Barbosa Alexandre Domingues, Duarte Ângela Luiza Branco Pinto, Oliveira Renê Donizeti Ribeiro, Louzada-Júnior Paulo, Donadi Eduardo Antônio, Crovella Sergio, Chies José Artur Bogo, Sandrin-Garcia Paula

Abstract excerpt

Rheumatoid arthritis (RA) is an autoimmune disease characterized by chronic inflammation and important joint commitment, being the most common systemic autoimmune disease worldwide. RA displays important genetic background with a variety of genes contributing to the immune balance breakdown. Recent studies have demonstrated that vitamin D, through its receptor (VDR), is able to regulate the immune balance and...

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PMID: 26686848
DOI: 10.1007/s11033-015-3937-z

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