Article
Vitamin D receptor (VDR) gene polymorphisms and susceptibility to systemic lupus erythematosus clinical manifestations.
Lupus - 1 Oct 2013
de Azevêdo Silva J, Monteiro Fernandes K, Trés Pancotto J A, Sotero Fragoso T, Donadi E A, Crovella S, Sandrin-Garcia P
Abstract excerpt
Systemic lupus erythematosus (SLE) is an autoimmune disorder with heterogeneous clinical manifestations and target tissue damage. Currently, several genes have been associated with SLE susceptibility, including vitamin D receptor (VDR), which is a mediator of immune responses through the action of vitamin D. Polymorphisms in the VDR gene can impair the vitamin D (D3) function role, and since SLE patients show...
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