High PRDM16 expression identifies a prognostic subgroup of pediatric acute myeloid leukaemia correlated to FLT3-ITD, KMT2A-PTD, and NUP98-NSD1: the results of the Japanese Paediatric Leukaemia/Lymphoma Study Group AML-05 trial.

doi:10.1111/bjh.13869

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Article

High PRDM16 expression identifies a prognostic subgroup of pediatric acute myeloid leukaemia correlated to FLT3-ITD, KMT2A-PTD, and NUP98-NSD1: the results of the Japanese Paediatric Leukaemia/Lymphoma Study Group AML-05 trial.

British journal of haematology - 1 Feb 2016

Shiba Norio, Ohki Kentaro, Kobayashi Tohru, Hara Yusuke, Yamato Genki, Tanoshima Reo, Ichikawa Hitoshi, Tomizawa Daisuke, Park Myoung-Ja, Shimada Akira, Sotomatsu Manabu, Arakawa Hirokazu, Horibe Keizo, Adachi Souichi, Taga Takashi, Tawa Akio, Hayashi Yasuhide

Abstract excerpt

Recent reports described the NUP98-NSD1 fusion as an adverse prognostic marker for acute myeloid leukaemia (AML) and PRDM16 (also known as MEL1) as the representative overexpressed gene in patients harbouring NUP98-NSD1 fusion. PRDM16 gene expression levels were measured via real-time polymerase chain reaction in 369 paediatric patients with de novo AML, of whom 84 (23%) exhibited PRDM16 overexpression...

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Identifiers

PMID: 26684393
DOI: 10.1111/bjh.13869

Genes

PRDM16
NSD1
NUP98
EFS
FLT3
ABL1
NPM1

Provenance

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High PRDM16 expression identifies a prognostic subgroup of pediatric acute myeloid leukaemia correlated to FLT3-ITD, KMT2A-PTD, and NUP98-NSD1: the results of the Japanese Paediatric Leukaemia/Lymphoma Study Group AML-05 trial.PMID 26684393Read ↗

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