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Article

PRDM16 expression is an independent prognostic factor in AML with the double-mutant NPM1/FLT3-ITD genotype.

Annals of hematology - 22 Jan 2026

Stasik Sebastian, Eckardt Jan-Niklas, Röllig Christoph, Baldus Claudia D, Serve Hubert, Müller-Tidow Carsten, Schäfer-Eckart Kerstin, Kaufmann Martin, Krause Stefan W, Hänel Mathias, Neubauer Andreas, Ehninger Gerhard, Platzbecker Uwe, Bornhäuser Martin, Schetelig Johannes, Middeke Jan M, Thiede Christian

Abstract excerpt

PRDM16 (PR Domain Containing 16) is a transcription factor that plays a critical role in hematopoietic stem cell maintenance. In acute myeloid leukemia (AML), PRDM16 overexpression is linked to specific cytogenetic risk groups and poor prognosis. However, in NPM1-mutated AMLs, PRDM16 expression varies widely, with no consensus on its prognostic significance. To understand molecular and clinical associations of...

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Source

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Identifiers

PMID: 41566085
DOI: 10.1007/s00277-026-06767-x
PMCID: PMC12823675

Genes

PRDM16
NPM1
FLT3
DNMT3A
IDH1
IDH2
TET2

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 23 Oct 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

PRDM16 expression is an independent prognostic factor in AML with the double-mutant NPM1/FLT3-ITD genotype.PMID 41566085Read ↗

Clinical features and prognostic impact of PRDM16 expression in adult acute myeloid leukemia.Semantic proximity Read ↗

High PRDM16 expression identifies a prognostic subgroup of pediatric acute myeloid leukaemia correlated to FLT3-ITD, KMT2A-PTD, and NUP98-NSD1: the results of the Japanese Paediatric Leukaemia/Lymphoma Study Group AML-05 trial.Semantic proximity Read ↗

High PRDM16 expression predicts poor outcomes in adult acute myeloid leukemia patients with intermediate cytogenetic risk: a comprehensive cohort study from a single Chinese center.Semantic proximity Read ↗

PRDM16 (1p36) translocations define a distinct entity of myeloid malignancies with poor prognosis but may also occur in lymphoid malignanciesSemantic proximity Read ↗

The combination of NPM1, DNMT3A, and IDH1/2 mutations leads to inferior overall survival in AMLSemantic proximity Read ↗

Only FLT3-ITD co-mutation did not have a deleterious effect on acute myeloid leukemia patients with NPM1 mutation, but concomitant with DNMT3A co-mutation or a < 3log reduction of MRD2 predicted poor survival.Semantic proximity Read ↗

PRDM16 Induces Methylation of FLT3 to Promote FLT3-ITD Signaling and Leukemia Progression.Semantic proximity Read ↗

PRDM16 isoforms differentially regulate normal and leukemic hematopoiesis and inflammatory gene signatureSemantic proximity Read ↗

Differential Expression of PRDM16 and PRDM14 in Myeloproliferative Neoplasms as Compared to Normal Bone Marrow: A Pilot StudySemantic proximity Read ↗

Measurable residual disease detected by flow cytometry independently predicts prognoses of NPM1-mutated acute myeloid leukemia.Semantic proximity Read ↗

Prognostic impact of DNMT3A mutation in acute myeloid leukemia with mutated NPM1.Semantic proximity Read ↗

Epigenetic dysregulation of NKD2 is a valuable predictor assessing treatment outcome in acute myeloid leukemiaSemantic proximity Read ↗

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