Article
Minimally invasive genomic and transcriptomic profiling of visceral cancers by next-generation sequencing of circulating exosomes.
Annals of oncology : official journal of the European Society for Medical Oncology - 1 Apr 2016
San Lucas F A, Allenson K, Bernard V, Castillo J, Kim D U, Ellis K, Ehli E A, Davies G E, Petersen J L, Li D, Wolff R, Katz M, Varadhachary G, Wistuba I, Maitra A, Alvarez H
Abstract excerpt
BACKGROUND: The ability to perform comprehensive profiling of cancers at high resolution is essential for precision medicine. Liquid biopsies using shed exosomes provide high-quality nucleic acids to obtain molecular characterization, which may be especially useful for visceral cancers that are not amenable to routine biopsies. PATIENTS AND METHODS: We isolated shed exosomes in biofluids from three patients with...
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