Article
Liquid Biopsy-Based Accurate Diagnosis and Genomic Profiling of Hard-to-Biopsy Tumors via Parallel Single-Cell Genomic Sequencing of Exfoliated Tumor Cells.
Analytical chemistry - 10 Sept 2024
Zhang Ziyuan, Liu Zhigang, Chen Lin, Wang Zhuo, Zhai Yangyang, Qian Peiyu, Zhao Yichun, Zhu Ling, Jiang Haowen, Wu Xubo, Shi Qihui
Abstract excerpt
Liquid biopsy provides a convenient and safer procedure for the diagnosis and genomic profiling of tumors that are inaccessible to biopsy by analyzing exfoliated tumor cells (ETCs) or tumor-derived cell-free DNA (cfDNA). However, its primary challenge lies in its limited accuracy in comparison to tissue-based approaches. We report a parallel single-ETC genomic sequencing (Past-Seq) method for the accurate...
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