Article
Meta-analysis of the relationship between slow acetylation of N-acetyl transferase 2 and the risk of bladder cancer.
Genetics and molecular research : GMR - 14 Dec 2015
An Y, Li H, Wang K J, Liu X H, Qiu M X, Liao Y, Huang J L, Wang X S
Abstract excerpt
The incidence of bladder cancer is closely associated with exposure to aromatic amines, that can cause cancer only after metabolic activation regulated by N-acetyl transferase 1 and 2 (NAT1 and NAT2). Many studies have indicated that slow acetylation of NAT2 increases the risk of bladder cancer. The major risk factor is tobacco smoke; however, some studies have failed to prove this. This study attempted to...
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