Article
Cigarette smoking, N-acetyltransferase 2 acetylation status, and bladder cancer risk: a case-series meta-analysis of a gene-environment interaction.
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology - 1 May 2000
Marcus P M, Hayes R B, Vineis P, Garcia-Closas M, Caporaso N E, Autrup H, Branch R A, Brockmöller J, Ishizaki T, Karakaya A E, Ladero J M, Mommsen S, Okkels H, Romkes M, Roots I, Rothman N
Abstract excerpt
Tobacco use is an established cause of bladder cancer. The ability to detoxify aromatic amines, which are present in tobacco and are potent bladder carcinogens, is compromised in persons with the N-acetyltransferase 2 slow acetylation polymorphism. The relationship of cigarette smoking with bladder cancer risk therefore has been hypothesized to be stronger among slow acetylators. The few studies to formally...
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