Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Let-7g reverses malignant phenotype of osteosarcoma cells by targeting Aurora-B.

International journal of clinical and experimental pathology - 1 Jan 2014

Liu Jia Ming, Long Xin Hua, Zhang Guo Mei, Zhou Yang, Chen Xuan Yin, Huang Shan Hu, Liu Zhi Li, Zhang Zhi Hong

Abstract excerpt

Accumulating studies revealed that the expression levels of several miRNAs are up or down-regulated in osteosarcoma (OS). The aim of this study was to investigate the functional significance and molecular of the let-7g in OS cells. The expression levels of let-7g was significantly down-regulated in OS cell lines U2-OS and HOS cell compared to osteoblast cell lines HOB cell. Moreover, bioinformatic prediction...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Aurora Kinase B
Share to Blotting, Western

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Bone Neoplasms

Share to Cell Survival

Share to MicroRNAs

Share to Neoplasm Invasiveness

Share to Osteosarcoma

Share to Real-Time Polymerase Chain Reaction

Source

Open in PubMed Open full text

Identifiers

PMID: 25197332
PMCID: PMC4152022

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Let-7g reverses malignant phenotype of osteosarcoma cells by targeting Aurora-B.PMID 25197332Read ↗

Let-7d miRNA Shows Both Antioncogenic and Oncogenic Functions in Osteosarcoma-Derived 3AB-OS Cancer Stem Cells.Semantic proximity Read ↗

Autophagy regulation by microRNAs : Novel insights into osteosarcoma therapySemantic proximity Read ↗

miR-766-3p suppressed tumorigenesis, epithelial-mesenchymal transition, and metastasis by targeting BCL9L via β -catenin signaling pathway in osteosarcoma cellsSemantic proximity Read ↗

LncRNA GAS5 suppresses the proliferation and invasion of osteosarcoma cells via the miR-23a-3p/PTEN/PI3K/AKT pathwaySemantic proximity Read ↗

Identification of genes that influence poor prognosis in osteosarcomaSemantic proximity Read ↗

Molecular Biology of OsteosarcomaSemantic proximity Read ↗

Deciphering the Signaling Mechanisms of Osteosarcoma TumorigenesisSemantic proximity Read ↗

miR‐874‐3p inhibits cell migration through targeting RGS4 in osteosarcomaSemantic proximity Read ↗

Osteosarcoma: prognosis plateau warrants retinoblastoma pathway targeted therapySemantic proximity Read ↗

Long non‑coding RNA NR2F1‑AS1 facilitates the osteosarcoma cell malignant phenotype via the miR‑485‑5p/miR‑218‑5p/BIRC5 axis.Semantic proximity Read ↗

Unraveling the roles of miRNAs in regulating epithelial-to-mesenchymal transition (EMT) in osteosarcomaSemantic proximity Read ↗

Elucidating the Role of let-7d-5p and OLR1 in Progression and Prognosis of Oral Squamous Cell Carcinoma via FAK/P53 Signaling axisSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.