Article
Genetic and molecular characterization of the human osteosarcoma 3AB-OS cancer stem cell line: a possible model for studying osteosarcoma origin and stemness.
Journal of cellular physiology - 1 Jun 2013
Di Fiore Riccardo, Fanale Daniele, Drago-Ferrante Rosa, Chiaradonna Ferdinando, Giuliano Michela, De Blasio Anna, Amodeo Valeria, Corsini Lidia R, Bazan Viviana, Tesoriere Giovanni, Vento Renza, Russo Antonio
Abstract excerpt
Finding new treatments targeting cancer stem cells (CSCs) within a tumor seems to be critical to halt cancer and improve patient survival. Osteosarcoma is an aggressive tumor affecting adolescents, for which there is no second-line chemotherapy. Uncovering new molecular mechanisms underlying the development of osteosarcoma and origin of CSCs is crucial to identify new possible therapeutic strategies. Here, we...
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