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Acquisition of cancer stem cell properties in osteosarcoma cells by defined factors

2 Oct 2020

Abstract excerpt

BACKGROUND: Cancer stem cells (CSCs) are considered to be responsible for tumor initiation, formation, and poor prognosis of cancer patients. However, the rarity of CSCs in clinical samples makes it difficult to elucidate characteristics of CSCs, especially in osteosarcoma (OS). The aim of this study is to verify whether it is possible to generate CSC-like cells by transducing defined factors into an OS cell...

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PMID: 33008481
DOI: 10.1186/s13287-020-01944-9

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