Article
Shear stress, arterial identity and atherosclerosis.
Thrombosis and haemostasis - 1 Mar 2016
Lehoux Stephanie, Jones Elizabeth A
Abstract excerpt
In the developing embryo, the vasculature first takes the form of a web-like network called the vascular plexus. Arterial and venous differentiation is subsequently guided by the specific expression of genes in the endothelial cells that provide spatial and temporal cues for development. Notch1/4, Notch ligand delta-like 4 (Dll4), and Notch downstream effectors are typically expressed in arterial cells along with...
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