Wall Shear Stress – an Important Determinant of Endothelial Cell Function and Structure – in the Arterial System in vivo

Abstract excerpt

It has been well established that wall shear stress is an important determinant of endothelial cell function and gene expression as well as of its structure. There is increasing evidence that low wall shear stress, as present in artery bifurcations opposite to the flow divider where atherosclerotic lesions preferentially originate, expresses an atherogenic endothelial gene profile. Besides, wall shear stress...

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