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Recombinant production platform for Group A Streptococcus glycoconjugate vaccines

22 Jan 2025

Abstract excerpt

Group A Streptococcus (Strep A) is a human-exclusive bacterial pathogen killing annually more than 500,000 patients, and no current licensed vaccine exists. Strep A bacteria are highly diverse, but all produce an essential, abundant, and conserved surface carbohydrate, the Group A Carbohydrate, which contains a rhamnose polysaccharide (RhaPS) backbone. RhaPS is a validated universal vaccine candidate in a...

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PMID: 39843476
DOI: 10.1038/s41541-025-01068-2

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