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Article

ATM, ATR and DNA-PKcs expressions correlate to adverse clinical outcomes in epithelial ovarian cancers

13 Aug 2014

Abstract excerpt

BACKGROUND: Ataxia-telangiectasia mutated (ATM), ataxia-telangiectasia mutated and rad3 related (ATR) and DNA-dependent protein kinase catalytic sub-unit (DNA-PKcs) play critical roles in DNA damage response (DDR) by linking DNA damage sensing to DDR effectors that regulate cell cycle progression and DNA repair. Our objective was to evaluate if ATM, ATR and DNA-PKcs expressions could predict response to therapy...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 26674120
DOI: 10.1016/j.bbacli.2014.08.001

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