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Article

Alterations of DNA damage response genes correlate with response and overall survival in anti-PD-1/PD-L1-treated advanced urothelial cancer.

Cancer medicine - 1 Dec 2020

Joshi Monika, Grivas Petros, Mortazavi Amir, Monk Paul, Clinton Steven K, Sue-Ann Woo Michele, Holder Sheldon L, Drabick Joseph J, Yin Ming

Abstract excerpt

DNA damage response (DDR) gene alterations in cancer are associated with a higher tumor mutational burden (TMB) and may impact clinical outcomes of urothelial cancer (UC). Here, we explore the prognostic role of DDR alterations in advanced UC treated with anti-PD-1/PD-L1 agents. The study included 53 patients who had FoundationOne genomic sequencing and received anti-PD-1/PD-L1 therapy. Fisher exact test and...

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Identifiers

PMID: 33098265
DOI: 10.1002/cam4.3552
PMCID: PMC7774722

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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