PLA2R antibody, PLA2R rs4664308 polymorphism and PLA2R mRNA levels in Tunisian patients with primary membranous nephritis.

doi:10.1371/journal.pone.0240025

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PLA2R antibody, PLA2R rs4664308 polymorphism and PLA2R mRNA levels in Tunisian patients with primary membranous nephritis.

PloS one - 1 Jan 2020

Dhaouadi Tarak, Abdellatif Jihen, Trabelsi Raja, Gaied Hanene, Chamkhi Sameh, Sfar Imen, Goucha Rym, Ben Hamida Fethi, Ben Abdallah Taieb, Gorgi Yousr

Abstract excerpt

BACKGROUND: Primary membranous nephritis (PMN) is an autoimmune disease induced by the deposit of antibodies (Ab) to the phospholipase receptor A2 receptor (PLA2R) on podocytes. In this context, we aimed to assess the relationships between anti-PLA2R Ab, PLA2R rs4664308 SNP, PLA2R mRNA levels and PMN susceptibility and outcome. METHODS: Sixty-eight PMN patients, 30 systemic lupus erythematosus (SLE) patients with...

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PMID: 33002091
DOI: 10.1371/journal.pone.0240025
PMCID: PMC7529277

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