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A Modified Approach to Inducing Bone Marrow Stromal Cells to Differentiate into Cells with Mature Schwann Cell Phenotypes.

Stem cells and development - 15 Feb 2016

Liu Yutian, Chen Jianghai, Liu Wei, Lu Xiaocheng, Liu Zhenyu, Zhao Xiaobo, Li Gongchi, Chen Zhenbing

Abstract excerpt

Marrow stromal cells (MSCs) can be induced to differentiate into Schwann-like cells under classical induction conditions. However, cells derived from this method are unstable, exhibiting a low neurotrophin expression level after the induction conditions are removed. In Schwann cell (SC) culture, progesterone (PROG) enhances neurotrophic synthesis and myelination, specifically regulating the expression of the...

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Identifiers

PMID: 26670188
DOI: 10.1089/scd.2015.0295

Genes

PMP22

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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