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Article

PDGF, NT-3 and IGF-2 in combination induced transdifferentiation of muscle-derived stem cells into Schwann cell-like cells.

PloS one - 1 Jan 2014

Tang Yi, He Hua, Cheng Ning, Song Yanling, Ding Weijin, Zhang Yingfan, Zhang Wenhao, Zhang Jie, Peng Heng, Jiang Hua

Abstract excerpt

Muscle-derived stem cells (MDSCs) are multipotent stem cells with a remarkable long-term self-renewal and regeneration capacity. Here, we show that postnatal MDSCs could be transdifferentiated into Schwann cell-like cells upon the combined treatment of three neurotrophic factors (PDGF, NT-3 and IGF-2). The transdifferentiation of MDSCs was initially induced by Schwann cell (SC) conditioned medium. MDSCs adopted a...

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Identifiers

PMID: 24454677
DOI: 10.1371/journal.pone.0073402
PMCID: PMC3891637

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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