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Directed Differentiation of Human Bone Marrow Stromal Cells to Fate-Committed Schwann Cells.

Stem cell reports - 10 Oct 2017

Cai Sa, Tsui Yat-Ping, Tam Kin-Wai, Shea Graham Ka-Hon, Chang Richard Shek-Kwan, Ao Qiang, Shum Daisy Kwok-Yan, Chan Ying-Shing

Abstract excerpt

Our ultimate goal of in vitro derivation of Schwann cells (SCs) from adult bone marrow stromal cells (BMSCs) is such that they may be used autologously to assist post-traumatic nerve regeneration. Existing protocols for derivation of SC-like cells from BMSCs fall short in the stability of the acquired phenotype and the functional capacity to myelinate axons. Our experiments indicated that neuro-ectodermal...

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Ganglia, Spinal
Mesenchymal Stem Cells
Myelin Sheath
Nerve Growth Factors
Neural Stem Cells

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PMID: 28890164
DOI: 10.1016/j.stemcr.2017.08.004
PMCID: PMC5639182

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