Article
Human Schwann cells retain essential phenotype characteristics after immortalization.
Stem cells and development - 10 Feb 2012
Lehmann Helmar C, Chen Weiran, Mi Ruifa, Wang Shuo, Liu Ying, Rao Mahendra, Höke Ahmet
Abstract excerpt
Schwann cells (SCs) play an important role in the pathogenesis of peripheral nerve diseases and represent a potential target for development of therapies. However, use of primary human SCs (hSCs) for in vitro models is limited because these cells are difficult to prepare and maintain in high yield and purity under common cell culture conditions. To circumvent this obstacle, we immortalized primary human fetal SCs...
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