Article
The HLA-B*35 allele modulates ER stress, inflammation and proliferation in PBMCs from Limited Cutaneous Systemic Sclerosis patients.
Arthritis research & therapy - 16 Dec 2015
Lenna Stefania, Assassi Shervin, Farina G Alessandra, Mantero Julio C, Scorza Raffaella, Lafyatis Robert, Farber Harrison W, Trojanowska Maria
Abstract excerpt
INTRODUCTION: HLA-B*35 is associated with increased risk of developing pulmonary hypertension in SSc patients. We previously reported that HLA-B*35 induces endothelial cell dysfunction via activation of ER stress/UPR and upregulation of the inflammatory response. Because PBMCs from lcSSc-PAH patients are also characterized by activation of ER stress/UPR and inflammation, the goal of this study was to assess...
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